Neural Platform Development
The ability to screen for drugs that can target the root causes of neural disorders, including pain and dysfunction in autism spectrum disorder.
Traditionally, neural diseases have been difficult to model in human systems because of the difficulty in accessing human neural tissues. Technology developed recently at the SCC-RI enables researchers to access neural tissues through the ability to directly convert blood cells to neural cells in vitro.
This project aims to adapt these converted cells to a high-throughput drug screening platform. This will build on the success of the already established high-throughput drug screening platform for cancer. In establishing a human neural screening platform, we now have the opportunity to address the underlying cellular causes of select neurological disorders including neuropathy and autism.