Targeted Differentiation of Human Pluripotent SCs
To develop cell-based tools for use in drug screening of patient-specific stem cells.
Human pluripotent stem cells provide an excellent model to study differentiation- the process by which all tissues found in the human body are generated. Understanding human pluripotency allows for greater control of differentiation towards cells and tissues which are otherwise difficult to obtain. Cellular programming enables scientists to convert human cell types, such as blood or skin obtained from an adult, to pluripotent stem cells in a patient-specific manner.
For example, in the Bhatia lab, we are currently using cellular programming technology to convert easy to obtain human blood into pain sensing neurons that would otherwise be very difficult if not impossible to obtain. These pain sensing neurons can be used to search for new drugs that prevent chemotherapy-induced peripheral neuropathy, among other applications.
|Karun Singh, PhD||Principal Investigator, Stem Cell and Cancer Research Institute (SCC-RI)|