Skip to main content
McMaster University Menu Search
Eva Szabo

Eva Szabo

Principal Investigator

Canada Research Chair in Metabolism in Human Stem Cells and Cancer Development

Assistant Professor, Department of Biochemistry and Biomedical Sciences & Department of Medicine

Contact Information

Location: MDCL 5022
Email: szabo@mcmaster.ca

Research

"We all have family and friends that are suffering from metabolic diseases, such as obesity, and we see the social stigma that comes with it. However, society doesn’t understand that obesity is a disease and should not be solely attributed to lifestyle choices. Therefore, my research is trying to understand how obesity develops, what causes downstream complications, and how we can treat these effectively, while simultaneously educating the public about the disease."

Dr. Eva Szabo’s research program is focused on metabolic diseases. She is particularly interested in obesity and type 2 diabetes, and their downstream complications, neuropathy and cardiovascular disease.

Through the use of reprogramming strategies, the Szabo lab is using patient-derived stem cells to create novel models of these diseases in vitro. These models allow the lab to determine both how resident stem cell populations are affected by metabolic diseases, and also how they can be harnessed towards the development of novel therapeutics.

The ultimate goal is to develop novel models of these diseases to address the gap in knowledge about how these conditions develop and how they can be treated in a targeted manner.

Projects

Understanding the role of genetics in early onset cardiovascular artery disease development to provide new therapeutic and risk management avenues.

Developing targeted, patient-specific treatment strategies for neuropathy induced by obesity and Type 2 Diabetes.

Developing novel and effective treatment strategies for obesity.

View All Projects

Lab Team

Picture Name Designation Focus Email More Info
Alexandria Afonso Alexandria Afonso Graduate Student
Kanwaldeep Singh Kanwaldeep Singh Graduate Student

Selected Publications

Direct conversion of human fibroblasts to multilineage blood progenitors.

Szabo E, Rampalli S, Risueño RM, Schnerch A, Mitchell R, Fiebig-Comyn A, Levadoux-Martin M, Bhatia M.

Nature. 2010 Nov 25;468(7323):521-6.

"It heralds a new age by discovering a role for 'directed differentiation' in the treatment of cancers and other disorders of the blood and immune system." - Dr. Samuel Weiss.

Molecular evidence for OCT4-induced plasticity in adult human fibroblasts required for direct cell fate conversion to lineage specific progenitors.

Mitchell R, Szabo E, Shapovalova Z, Aslostovar L, Makondo K, Bhatia M.

Stem Cells. 2014 Aug;32(8):2178-87.

“The research highlights the importance of a single factor and culture conditions for derivation of multipotent lineage specific progenitors." - Dr. Eva Szabo

View more Publications

Support

Canada Research Chairs-logo
Ministry of Research and Innovation-logo
Canadian Foundation for Innovation-logo
Canadian Institutes of Health Research-logo