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Jon Draper

Jon Draper

Principal Investigator

Canada Research Chair in Human Stem Cell Lineage Commitment

Associate Professor, Department of Pathology and Molecular Medicine

Contact Information

Location: MDCL 5032
Email: draperj@mcmaster.ca
Website: thedraperlab.com

Research

Dr. Jon Draper’s research program is focused on studying human stem cell lineage commitment. His group explores cell fate mechanisms and how they function to determine cell identity, with a special focus on lung tissue and lung diseases. Dr. Draper is interested in determining how a new understanding of cell fate machinery can be practically applied to direct cells towards specific fates.

To this end, the Draper lab is developing new models of healthy lung tissue and lung diseases including pulmonary fibrosis and lung cancer. Through the use of reprogramming strategies, Dr. Draper has successfully created human lung tissues that provide his laboratory with a unique avenue for interrogating the cellular and molecular mechanisms that underlie lung function and disease development.

Early detection is difficult in many lung diseases because they don't tend to manifest until quite late in the disease stage. As a result, studying the onset and progression of lungh diseases is challenging. The Draper lab’s ability to model these diseases in vitro allows them to address this challenge and provides them with new insights into the genetic changes taking place at each stage of disease.


Projects

The development of new in vitro human-specific lung cancer models.

View All Projects

Lab Team

Picture Name Designation Focus Email More Info
Sonam Bhatia Sonam Bhatia Graduate Student
Daisy Deng Daisy Deng Graduate Student
Amanda Hrenczuk Amanda Hrenczuk Graduate Student
Rohan Nadkarni Rohan Nadkarni Graduate Student

Selected Publications

Lengthened G1 Phase Indicates Differentiation Status In Human Embryonic Stem Cells.

Calder A, Roth-Albin I, Bhatia S, Pilquil C, Lee JH, Bhatia M, Levadoux-Martin M, McNicol J, Russell J, Collins T, Draper JS.

Stem Cells Development. 2013 15;22(2):279-95.

Treatment-induced cell cycle kinetics dictate tumor response to chemotherapy.

Hallett RM, Huang C, Motazedian A, Auf der Mauer S, Pond GR, Hassell JA, Nordon RE, Draper JS.

Oncotarget. 2015 Mar 30;6(9):7040-52.

Demarcation of stable subpopulations within the pluripotent hESC compartment.

Bhatia S, Pilquil C, Roth-Albin I & Draper JS.

PLoS One.2013;8(2):e57276.

View more Publications

Support

Canada Research Chairs-logo
Ontario Thoracic Society - Ontario Lung Association-logo
Stem Cell Network-logo
Canadian Foundation for Innovation-logo
Canadian Institutes of Health Research-logo
Canadian Cancer Society-logo