Skip to main content
McMaster University Menu Search
Sheila Singh

Sheila Singh

Principal Investigator

Canada Research Chair in Human Cancer Stem Cell Biology

Director, McMaster Surgeon-Scientist Program

Contact Information

Location: MDCL 5027
Email: ssingh@mcmaster.ca

Research

“You see a lot of things in pediatric neurosurgery and all of them — good and bad — inspire my research.  And every person who works with me has a direct connection to the ‘Why?’ of research.  Very often patients and their families will come for a tour of the lab and my people get to meet them.  There is a real connection. People in my lab work twice as hard because they have that direct motivation."

Dr. Sheila Singh’s research program is dedicated to applying a developmental neurobiology approach to the study of human brain tumours. As a pediatric neurosurgeon, Dr. Singh is acutely aware of the needs of patients and clinicians dealing with these diseases. Her unique perspective as a surgeon-scientist guides her research questions and areas of focus.

The three types of tumours studied by Dr. Singh’s lab are glioblastoma, medulloblastoma and brain metastases. The lab employs a stem cell biology framework to the study of these cancers to identify and target the molecular mechanisms responsible for their development. Their goal is to determine which treatment refractory cells are leading to relapse and recurrence in patients.

Ultimately, Dr. Singh’s goal is to be able to take more targeted and effective therapies back to the clinic. To ensure that all of their findings have the potential to be clinically relevant, the Singh lab has cultivated a specialty in developing pre-clinical models and are steadfast in their commitment to working with brain tumour samples direct from human patients.

Projects

Demonstrating the ability of the Wnt pathway to suppress tumour progression in childhood medulloblastoma, thus establishing activated Wnt signaling as a novel treatment paradigm.

Targeting STAT3 may provide a novel therapeutic strategy for patients with group 3 and recurrent group 3 medulloblastoma.

Providing the foundation for devising clinical trials to further investigate PTC-028 as a therapeutic option for the treatment of recurrent medulloblastoma.

Identifying novel therapeutics that block the metastatic process and validating the predictive ability of our brain metastases signature

A promising lead panel of biotherapeutic modalities will ultimately be translated into early clinical development, generating targeted therapies for glioblastoma patients.

View All Projects

Lab Team

Picture Name Designation Focus Email More Info
David Bakhshinyan David Bakhshinyan Graduate Student
Chirayu Chokshi Chirayu Chokshi Graduate Student
Michelle Kameda-Smith Michelle Kameda-Smith Graduate Student
Branavan Manoranjan Branavan Manoranjan Graduate Student
Maleeha Qazi Maleeha Qazi Graduate Student
Neil Savage Neil Savage Technical Staff
Mohini Singh Mohini Singh Graduate Student
Minomi Subapanditha Minomi Subapanditha Technical Staff
Chitra Venugopal Chitra Venugopal Research Associate
Parvez Vora Parvez Vora Post-Doctoral Fellow
Nick Yelle Nick Yelle Graduate Student

Selected Publications

Pyrvinium Targets CD133 in Human Glioblastoma Brain Tumor-Initiating Cells.

Venugopal C, Hallett R, Vora P, Manoranjan B, Mahendram S, Qazi MA, McFarlane N, Subapanditha M, Nolte SM, Singh M, Bakhshinyan D, Garg N, Vijayakumar T, Lach B, Provias JP, Reddy K, Murty NK, Doble BW, Bhatia M, Hassell JA, Singh SK.

Clinical Cancer Research. 2015 Dec 1;21(23):5324-37.

A cancer stem cell model for studying brain metastases from primary lung cancer.

Nolte SM, Venugopal C, McFarlane N, Morozova O, Hallett RM, O'Farrell E, Manoranjan B, Murty NK, Klurfan P, Kachur E, Provias JP, Farrokhyar F, Hassell JA, Marra M, Singh SK.

Journal of the National Cancer Institute. 2013 Apr 17;105(8):551-62.

FoxG1 interacts with Bmi1 to regulate self-renewal and tumorigenicity of medulloblastoma stem cells.

Manoranjan B, Wang X, Hallett RM, Venugopal C, Mack SC, McFarlane N, Nolte SM, Scheinemann K, Gunnarsson T, Hassell JA, Taylor MD, Lee C, Triscott J, Foster CM, Dunham C, Hawkins C, Dunn SE, Singh SK.

Stem Cells. 2013 Jul;31(7):1266-77.

View more Publications