Cancer is the leading cause of death in Canada. Two cancers we are particularly focused on are Acute Myeloid Leukemia (AML), a lethal cancer of the blood system, and Glioblastoma Multiforme (GBM), an aggressive brain cancer with an unsettlingly high recurrence rate. Our approach is to further our understanding of the cells implicated in these diseases to ultimately determine how they can be predicted, managed and eliminated.
To identify novel therapeutics that can target the bone marrow environment to destroy and prevent leukemia. By better understanding the optimal bone marrow conditions needed to support healthy blood stem cells, this study also has the potential to improve stem cell transplantation therapies.