Assistant Professor, Department of Biochemistry and Biomedical Sciences and Department of Medicine (Division of Endocrinology & Metabolism)
The Szabo lab focuses on dissecting the functional, molecular and genetic interplay between adipocyte development (from adult and pluripotent sources) and metabolic disease pathogenesis. Adipose tissue dysfunction and abnormal preadipocyte proliferation and differentiation results in obesity and increases the chance of developing type II diabetes and cancers. Moreover, adipocytes were shown to posses the capacity to alter pharmacokinetics and/or induce drug resistance by secretion of adipokines. Thus, understanding human adipose tissue development and underlying mechanism of aberrant adipocyte regulation may provide novel therapeutic targets for management of obesity, diabetes and cancers.
Current projects include: 1. Establishment of a robust differentiation system to study both white and brown adipocyte development in humans, as well as disease models for obesity and type II diabetes that can be utilized for understanding these devastating diseases and development of new treatment strategies; 2. Development of human preadipocyte models for the characterization of cellular and molecular event involved in preadipocyte generation providing a method for studying the mechanisms underlying normal and excessive adipose tissue development and establishment of novel drug screening platforms. Projects within the lab encompass human embryonic and adult stem cell, hiPSC and direct reprogramming technologies to address the link between adipocyte development and metabolic diseases or neoplastic transformation/maintenance.
2008 - 2012 — Postdoctoral Fellow, Stem Cell & Cancer Research Institute, McMaster University
2003 - 2007 — Ph.D, Institute of Medical Sciences, University of Toronto
1999 - 2003 — M.Sc, Department of Biology, York University
1995 - 1999 — B.Sc Honours, York University
|2010 - 2012||MITACS Strategic Postdoctoral Fellowship|
|2011||MITACS Postdoctoral Award for Outstanding Research Achievement|
|2009 - 2010||Ministry of Research and Innovation Postdoctoral Fellowship|
|2003 - 2007||University of Toronto IMS Open Fellowship|
|2005 - 2006||Heart and Stroke Foundation of Canada - OGSST|
|2003 - 2004||University of Toronto Continuing Student Fellowship|
|1996 - 1997||Mount Sinai Volunteering Award for over 500 hours of volunteering|
|1995 - 1996||York University Entrance and Science Scholarship|
Lee JH, Lee JB, Shapovalova Z, Fiebig-Comyn A, Mitchell RR, Laronde S, Szabo E, Benoit YD, Bhatia M. Somatic transcriptome priming gates lineage-specific differentiation potential of human-induced pluripotent stem cell states. Nature Communications. 2014 Dec 3; 5:5605. doi: 10.1038/ncomms6605. PMID: 25465724
Mitchell RR, Szabo E, Shapovalova Z, Aslostovar L, Makando K, Bhatia M. Molecular evidence for Oct-4 induced plasticity in adult human fibroblasts required for direct cell fate conversion to lineage- specific progenitors. Stem Cells. 2014 Apr 16. doi: 10.1002/stem.1721. Epub ahead of print, PMID: 24740884
Mitchell RR, Szabo E, Case DT, Lee JH, Lee JB, McNicol J, Alamilla J, Gillespie D, Fiebig-Comyn A, Bhatia M. Activation of neural cell fate programs towards direct conversion of adult human fibroblasts to tri-potent neural progenitors using Oct-4. Stem Cells and Development. 2014 Apr 2. EPub ahead of print. PMID: 24694094
Risueño RM, Sachlos E, Lee JH, Lee JB, Hong SH, Szabo E, Bhatia M. Inability of human iPSC-hematopoietic derivatives to downregulate miRNAs in vivo reveals a block in xenograft hematopoietic regeneration. Stem Cells. 2012 30(2): 131-139. doi: 10.1002/stem.1684.
Szabo E, Rampalli S, Risueño RM, Schnerch A, Mitchell R, Fiebig-Comyn A, Levadoux-Martin M, and Bhatia M. Direct conversion of human fibroblasts to multilineage blood progenitors. Nature. 2010 Nov; 468(7323):521-6. doi:10.1038/nature09591. Epub 2010 Nov 7.
Vijayaragavan K, Szabo E, Bossé M, Ramos-Mejia V, Moon R, Bhatia M. Noncanonical Wnt Signaling Orchestrates Early Developmental Events toward Hematopoietic Cell Fate from Human Embryonic Stem Cells. Cell Stem Cell 2009 Mar. Vol 4 (3), pg 248-62. doi:10.1016/j.stem.2008.12.011.
|2012 - Present||Chair of Stem Cell Network Training and Communications Committee|
|2012 - Present||Stem Cell Network Research Management Committee Member|
|2011 - Present||Editorial Board member of ISRN Cell Biology|
|2011 - 2012||Stem Cell Network Training and Communications Committee Member|
|2011 - Present||Stem Cell Network Training and Education Committee Member|
|2011 - Present||MITACS Scientific Review Committee Member|
|2008 - Present||The Connolly Memorial OSOTF Award Committee Member|
|2008 - 2012||Co-Chair of the McMaster University FHS Post-doctoral Fellow's Asosciation|