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Pre-Clinical Modelling

Pre-clinical modelling is a critical transitional step in determining whether research findings are physiologically relevant. This step is essential for bringing in vitro findings to testing in human clinical trials. Our approach is to continuously innovate new models of disease to begin testing early in the research process, ultimately ensuring translational capacity.

Principal Investigators

Brad Doble

Brad Doble

Principal Investigator

Jon Draper

Jon Draper

Principal Investigator

Kristin Hope

Kristin Hope

Principal Investigator

Karun Singh

Karun Singh

Principal Investigator

Sheila Singh

Sheila Singh

Principal Investigator

Related Projects

Screening for repurposed drugs that rescue our preclinical TAO2 autism spectrum disorder models, and working to move these into Phase I clinical trials.

Informing the design of targeted anti-leukemic therapies to improve treatment options and outcomes for patients with this disease.

Insight into the specialized cellular machinery that functions in blood stem cells paves the way to developing new strategies to amplify these cells for regenerative medicine.

Related News

SCCRI uncovers unexpected cells responsible for leukemia relapse, offering new leads for therapy

SCCRI uncovers unexpected cells responsible for leukemia relapse, offering new leads for therapy

The Bhatia Lab has characterised the process of how leukemia cells initially respond to treatment but retaliate after chemotherapy. Findings help predict the risk of disease recurrence and can be therapeutically used to prevent relapse. [...]

Lili Aslostovar

Lili Aslostovar | Wednesday, September 12, 2018

SCC-RI scientist unravels genetic mystery causing complex brain disorders, including autism

SCC-RI scientist unravels genetic mystery causing complex brain disorders, including autism

Dr. Karun Singh and his team pinpoint key genes causing brain development disorders [...]

Karun Singh

Karun Singh | Monday, March 5, 2018

StemCellTalks 2018 at McMaster University Brings Discussions of Making Sci-Fi Medicine a Modern Reality

StemCellTalks 2018 at McMaster University Brings Discussions of Making Sci-Fi Medicine a Modern Reality

StemCellTalks coordinator, Damian Tran, recounts the inspiring moments of the symposium, which aimed to engage senior high school students with introductory stem cell biology. [...]

Damian Tran

Damian Tran | Thursday, March 29, 2018