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Cancer

Cancer is the leading cause of death in Canada. Two cancers we are particularly focused on are Acute Myeloid Leukemia (AML), a lethal cancer of the blood system, and Glioblastoma Multiforme (GBM), an aggressive brain cancer with an unsettlingly high recurrence rate. Our approach is to further our understanding of the cells implicated in these diseases to ultimately determine how they can be predicted, managed and eliminated.

Principal Investigators

Mick Bhatia

Mick Bhatia

Director and Senior Scientist

Brad Doble

Brad Doble

Principal Investigator

Jon Draper

Jon Draper

Principal Investigator

Kristin Hope

Kristin Hope

Principal Investigator

Sheila Singh

Sheila Singh

Principal Investigator

Related Projects

To identify novel therapeutics that can target the bone marrow environment to destroy and prevent leukemia. By better understanding the optimal bone marrow conditions needed to support healthy blood stem cells, this study also has the potential to improve stem cell transplantation therapies.

The combination of standard of care chemotherapy, coupled with novel drugs discovered by our group, is hoped to prevent cancer relapse.

Demonstrating the ability of the Wnt pathway to suppress tumour progression in childhood medulloblastoma, thus establishing activated Wnt signaling as a novel treatment paradigm.

Related News

New genes discovered regulating brain metastases in lung cancer patients

New genes discovered regulating brain metastases in lung cancer patients

 Dr. Sheila Singh’s research team has identified new regulators of brain metastases, the most common brain tumour in adults and the leading cause of death in cancer patients. [...]

Tina Depko

Tina Depko | Tuesday, August 8, 2017

Dr. Sheila Singh named to The College of New Scholars, Artists, and Scientists

Dr. Sheila Singh named to The College of New Scholars, Artists, and Scientists

Congratulations Dr. Sheila Singh on receiving this prestigious recognition! [...]

Darlene Lane

Darlene Lane | Friday, November 24, 2017

New insights made into cellular-signalling pathway linked to cancer and other diseases

New insights made into cellular-signalling pathway linked to cancer and other diseases

Dr. Brad Doble's lab has revealed important insights into the regulation of the cell signalling pathway Wnt, which is strongly implicated in the development of colon and other types of cancer. [...]

Tina Depko

Tina Depko | Monday, September 11, 2017